Method of assessing risk for cardiovascular disease and other disorders and phytosterol-based compositions useful in preventing and treating cardiovascular disease and other disorders
AssigneeForbes Medi-Tech Inc.
InventorEgon Novak
Life of this patent
Estimating the term…
Abstract
Methods are provided for determining whether a subject animal has an increased risk of cardiovascular or related disorder. The level of serum campesterol and beta-sitosterol are determined and a campesterol/beta-sitosterol ratio obtained. The ratio determined for the subject animal is compared with that of a normal control animal and correlated with the risk of cardiovascular or a related disorder.
Claims13
A method of assessing in a subject animal a risk for cardiovascular disease or a related disorder, comprising:
- obtaining a serum sample from the subject animal;
- determining a campesterol level in the serum sample;
- determining a beta-sitosterol level in the serum sample;
- dividing the campesterol level by the beta-sitosterol level to determine a campesterol/beta-sitosterol ratio;
- comparing said campesterol/beta-sitosterol ratio with a campesterol/beta-sitosterol ratio determined for a serum sample obtained from a normal control animal;
- and
- correlating a low campesterol/beta-sitosterol ratio for the serum sample from the subject animal as compared to the campesterol/beta-sitosterol ratio for the serum sample from the normal control animal with the risk for cardiovascular disease or a related disorder.
A method of assessing in a subject animal a risk of cardiovascular disease and lipid disorders comprising:
- determining in the subject animal a ratio of serum campesterol to beta-sitosterol;
- determining in the subject animal a level of serum total phytosterol;
- determining in the subject animal a level of serum total cholesterol;
- comparing said ratio of serum campesterol to beta-sitosterol, said level of serum total phytosterol and said level of serum total cholesterol so determined to a respective ratio of serum campesterol to beta-sitosterol, level of serum total phytosterol and level of serum total cholesterol determined for a serum sample from a normal control animal;
- and
- correlating a low campesterol/beta-sitosterol ratio, a high serum total phytosterol level and a high serum total cholesterol level for the serum sample from the subject animal as compared to the campesterol/beta-sitosterol ratio, the serum total phytosterol level and the serum total cholesterol level for the serum sample from the normal control animal with the risk for cardiovascular disease and lipid disorders.
A method of assessing in a subject animal a risk for cardiovascular disease and a related disorder comprising determining in said subject animal a level of serum total phytosterol and a level of serum total cholesterol and comparing said levels to respective levels in serum of a normal control animal wherein:
- a high serum total phytosterol level and low serum total cholesterol level as compared to said levels in the normal control animal indicates a subject animal not requiring therapeutic or dietary intervention;
- a high serum total phytosterol level and high serum total cholesterol level as compared to said levels in the normal control animal indicates a subject animal at risk for lipid metabolic disorders;
- a low serum total phytosterol level and low serum total cholesterol level as compared to said levels in the normal control animal indicates a subject animal at risk for diabetes or hypothyroidism;
- and
- a low serum total phytosterol level and high serum total cholesterol level as compared to said levels in the normal control animal indicates an animal at risk for cardiovascular disease.
Dependencies are inferred from the claim text.