Host defense enhancement
AssigneeThe Regents of the University of California
InventorsAndrea J. Tenner, Ronald R. Nepomuceno
Life of this patent
Estimating the term…
Abstract
Nucleic and amino acid sequences for a novel cell surface transmembrane glycoprotein designated ClqR.sub.P are taught. A method by which the nucleic acid sequence encoding ClqR.sub.P may be used to modulate the role of the immune system is also described. Transgenic animals created with heterologous DNA sequence encoding ClqR.sub.P are described as well as antibodies directed against the ClqR.sub.P protein. A method of hybridization for ClqR.sub.P nucleic acid using oligonucleotide probes based on the ClqR.sub.P nucleic acid sequence and methods for detecting a hybrid probe:target ClqR.sub.P duplex are also taught including a kit for such detection.
Claims10
An isolated nucleic acid molecule encoding an amino acid sequence as set forth in SEQ ID NO:2.
An isolated nucleic acid molecule having a nucleotide sequence as set forth in SEQ ID NO:1.
An isolated nucleic acid molecule selected from the group consisting of:
- a) the nucleotide sequence of SEQ ID NO:
- 1, where T can also be U;
- b) a nucleic acid sequence that hybridizes to the nucleotide sequence of SEQ ID NO:
- 1 or to the complement of the nucleotide sequence of SEQ ID NO:
- 1, and encodes a ClqR.sub.P protein;
- c) a fragment of a) that comprises 15 nucleotides;
- and
- d) SEQ ID NO:1.
A method for delivery and expression of ClqR.sub.P in a target cell, wherein the method comprises:
- a) delivering a nucleic acid encoding ClqR.sub.P into a target cell, in vitro;
- and
- b) expressing said nucleic acid inside the target cell.
Dependencies are inferred from the claim text.