Bioactive substance having antitumor activity, producing strain, and production thereof
AssigneeSenka Co.
InventorHidenao Takazawa
Life of this patent
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Abstract
Asn-linked glycoprotein having antitumor activity, with molecular weight of 32-84 kDa, its producing strain, production and use, adsorbs to Con. A. The process for its production comprises culturing a microorganism belonging to genus Aspergillus and isolating from the culture medium Asn-linked glycoprotein having a molecular weight of 32-84 kDa which adsorbs to Con. A, or a mixture thereof. The substance having antitumor activity is effective for treatment of solid tumors, ascites tumors, multiple cytoma and oval tumors and for the suppression of tumors.
Claims15
An isolated and purified Asn-linked glycoprotein having a molecular weight of 32-48 kDa, which absorbs to Con. A.
An isolated and purified microorganism which is Aspergillus flavus SRT (FERM BP-5030).
A process for the production of Asn-linked gycoproteins having a molecular weight of 32-84 kDa, which adsorbs to Con. A, comprising culturing an isolated and purified microorganism which is Aspergillus Flavus SRT (FERM BP-5030) and isolating the thus-produced Asn-linked glycoprotein having a molecular weight of 32-84 kDa, which adsorbs to Con. A.
Antitumor active agent which contains a microorganism which is Asperqillus flavus SRT (FERM BP-5030) which produces an Asn-linked glycoprotein having a molecular weight of 32-84 kDa, which adsorbs to Con. A, a cell lysate thereof, and a said Asn-linked glycoprotein as active ingredients.
Dependencies are inferred from the claim text.