Human protein kinases hYAK3

An isolated polynucleotide comprising a nucleotide sequence which encodes a polypeptide having a serine/threonine kinase activity and which hybridizes under stringent conditions to a nucleotide sequence encoding the polypeptide of SEQ ID NO:4, wherein the stringent hybridization conditions are under overnight incubation at 42.degree. C. in a solution which comprises 50% formamide, 5.times. SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5.times. Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA;

• and is followed by washing the filter in 0.1.times. SSC at about 65.degree. C.

An isolated polynucleotide comprising a nucleotide sequence which encodes a polypeptide having a serine/threonine kinase activity and which hybridizes under stringent conditions to a nucleotide sequence of SEQ ID NO:

• 1, wherein the stringent hybridization conditions are under overnight incubation at 42.degree. C. in a solution which comprises 50% formamide, 5.times. SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5.times. Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denaned, sheared salmon sperm DNA;
• and is followed by washing the filter in 0.1.times. SSC at about 65.degree. C.

An isolated polynucleotide comprising a nucleotide sequence which encodes a polypeptide having a serine/threonine kinase activity and which hybridizes under stringent conditions to a nucleotide sequence of SEQ ID NO:

• 3, wherein the stringent hybridization conditions are under overnight incubation at 42.degree. C. in a solution which comprises 50% formamide, 5.times. SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5.times. Denhardt's solution, 10% dextran sulfate, and 20 microgram/ml denatured, sheared salmon sperm DNA;
• and is followed by washing the filter in 0.1.times. SSC at about 65.degree. C.

An isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of SEQ ID NO:2.

An isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of SEQ ID NO:4.

An isolated polynucleotide which comprises the polynucleotide of SEQ ID NO:

• 1.

An isolated polynucleotide which comprises the polynucleotide of SEQ ID NO:

• 3.

An expression system comprising a DNA or RNA molecule, where said expression system is capable of producing the polypeptide of SEQ ID NO:

• 2, or an allelic variant thereof, when said expression system is present in a compatible host cell.

An expression system comprising a DNA or RNA molecule, wherein said expression system is capable of producing the polypeptide of SEQ ID NO:

• 4, or an allelic variant thereof, when said expression system is present in a compatible host cell.