Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
AssigneeGenetics Institute, Inc.
InventorsAnthony J. Celeste, Beth L. Murray
Life of this patent
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Abstract
Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Claims14
An isolated DNA molecule comprising a DNA sequence selected from the group consisting of:
- (a) nucleotides #1, 511 or 538 to #837 or 840 of SEQ ID NO:1;
- (b) nucleotides encoding amino acids #-170, 1 or 10 to #109 or 110 of SEQ ID NO:2;
- and
- (c) naturally occurring human allelic sequences and equivalent degenerative codon sequences of (a) or (b).
An isolated DNA molecule comprising a DNA sequence consisting of nucleotides # 511 to #840 of SEQ ID NO:1.
A chimeric DNA molecule comprising a DNA sequence encoding a propeptide from a member of the TGF-.beta. superfamily of proteins linked in frame to a DNA sequence encoding a bone morphogenetic protein-16 (BMP-16) polypeptide, said BMP-16 polypeptide comprising amino acid # 1 to # 110 of SEQ ID NO:2.
An isolated DNA molecule comprising a DNA sequence which encodes an amino acid sequence consisting of amino acids 1 to 110 of SEQ ID NO:2.
A DNA molecule obtained from the clone deposited as American Type Culture Collection Accession Number 98084.
Dependencies are inferred from the claim text.