Purified mammalian NK antigens and related reagents
AssigneeSchering Corporation
InventorsChiwen Chang, Lewis L. Lanier, Joseph H. Phillips, Jr.
Life of this patent
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Abstract
NK cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using those reagents and diagnostic kits are also provided.
Claims28
A composition selected from the group consisting of:
- a) a recombinant or isolated nucleic acid encoding at least 10 contiguous amino acids of SEQ ID NO:
- 2;
- b) a substantially pure polypeptide comprising at least 10 contiguous amino acids of SEQ ID NO:
- 2;
- and
- c) an antibody raised to a recombinant or purified primate DX1 protein.
A recombinant or isolated nucleic acid encoding at least 12 contiguous amino acids from a primate DX1 protein (see SEQ ID NO:
- 2).
A substantially pure polypeptide comprising at least 12 contiguous amino acids from a primate DX1 protein (see SEQ ID NO:
- 2).
A method of screening a sample for a ligand for DX1 comprising the steps of producing a purified or recombinant primate DX1 protein, and screening in said sample for a specific binding of said ligand to said DX1 protein.
A method of modulating physiology or development of a cell comprising contacting said cell with an agonist or antagonist of a primate DX1 protein.
An isolated or recombinant nucleic acid comprising at least 35 contiguous nucleotides of the coding portion from SEQ ID NO:
- 1.
A substantially pure polypeptide comprising at least 22 contiguous amino acids from SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.