Human lymph node derived GTPase
AssigneeZeneca Limited
InventorsJulie Yan Pan, Mark Egerton, David Shay Silberstein
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Abstract
A novel human GTPase polypeptide intracellular molecular switch is described. A full length cDNA which encodes the signal transduction polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the human GTPase. Methods are provided to identify compounds that modulate the biological activity of the native signal switch biomolecule and hence regulate cellular and tissue physiology.
Claims7
A purified polynucleotide comprising a nucleic acid sequence encoding the polypeptide having the sequence as depicted in SEQ ID NO:3 or a variant of SEQ ID NO:3 that differs from SEQ ID NO:3 by one or more conservative amino acid substitutions.
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