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US 5,965,349 AGranted
Methods of photodecontamination using synthetic media
AssigneeCerus Corporation
InventorsLily Lin, Laurence Corash
Life of this patent
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Abstract
Methods of photodecontamination are described which employ phosphate buffered aqueous solutions. Blood products comprising plasma are diluted with these solutions and treated with psoralen.
Claims5
A method of treating a blood preparation, comprising:
- a) providing, in any order,
- i) a blood product,
- ii) a phosphate buffered, aqueous synthetic medium, said medium being devoid of bicarbonate and comprising glucose, 80-100 mM sodium chloride, and 10-15 mM sodium citrate,
- iii) a psoralen derivative, and
- iv) means for activating said psoralen derivative;
- b) adding said phosphate buffered, aqueous synthetic medium to said blood product to create a blood preparation;
- c) adding said psoralen derivative to said blood preparation;
- and
- d) treating said blood preparation by activating said psoralen derivative with said activating means to create a treated blood preparation.
6 more elements
A method of treating a blood preparation, comprising:
- a) providing, in any order,
- i) a blood product comprising plasma,
- ii) a phosphate buffered, aqueous synthetic medium, said medium being devoid of bicarbonate and comprising glucose, 80-100 mM sodium chloride, and 10-15 mM sodium citrate, and a psoralen derivative, and
- iii) means for activating said psoralen derivative;
- b) removing a portion of said plasma from said blood product;
- c) adding said phosphate buffered, aqueous synthetic medium to said blood product to create a blood preparation;
- d) treating said blood preparation by activating said psoralen derivative with said activating means to create a treated blood preparation.
4 more elements
Dependencies are inferred from the claim text.