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US 5,965,258 AGranted
Elongated microstructures from perfluoroalkylated amphiphiles
AssigneeAlliance Pharmaceutical Corp.
InventorsJean G. Riess, Francoise Giulieri, Marie-Pierre Krafft, Leila Zarif
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Abstract
Microstructures formed from fluorinated amphiphiles and mixed fluorinated and non-fluorinated amphiphiles and having the geometry of tubules, helixes and fibers and methods for preparing them. Tubular forms are capable of encapsulating or incorporating bioactive agents or other useful substances for controlled release in vivo.
Claims31
A supramolecular microstructure having a generally elongated cylindrical geometry comprising fluorinated amphiphiles of the formula:
- R.sup.1 (R.sup.2)-X-Y I
- wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of linear or branched, saturated or unsaturated alkyl chains and linear or branched, saturated or unsaturated perfluoroalkyl chains having 4 to 24 carbon atoms with at least one perfluoroalkylated segment wherein said alkyl chains and said perfluoroalkyl chains may be substituted with N, S or O;
- X is a spacer arm selected from the group consisting of linear or branched, saturated or unsaturated alkyl chains, amino acids, peptides and combinations thereof wherein said alkyl chains may be substituted with N, S, O or NHC(O);
- and
- Y is selected from the group consisting of phosphoramides, phosphoryl moieties, monosaccharides, disaccharides, opened disaccharides and combinations thereof wherein said fluorinated amphiphiles aggregate to form said supramolecular microstructure.
2 more elements
Dependencies are inferred from the claim text.