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US 5,965,167 AGranted
Dosage units
OwnerPradeepkumar P. Sanghvi, David P. Prior +2inventors
InventorsPradeepkumar P. Sanghvi, David P. Prior, Djelila Mezaache, Scott J. Szedlock
Life of this patent
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Abstract
The invention relates to a novel dosage unit for the sustained-release delivery of active agents as well as compositions and methods for making same.
Claims14
A composition suitable for making a sustained release dosage unit comprising suitable amounts of:
- (A) microspheres produced by imposing liquiflash conditions on a binary feedstock containing an active agent and processing aid;
- and
- (B) a coating containing a blend of polymers having different levels of hydrophilicity.
A method of making a dosage unit comprising the steps:
- (1) subjecting a binary mixture consisting essentially of an active agent and a processing aid selected from the group consisting of waxes to liquiflash conditions to yield microspheres, wherein the weight ratio of said active agent to said processing aid is in the range of 95:5 to 80:20;
- (2) coating the microspheres of step (1) with a blend of polymers having different levels of hydrophilicity.
Dependencies are inferred from the claim text.