Self-emulsifiable formulation producing an oil-in-water emulsion
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsSimon Benita, Jackie Kleinstern, Tatyana Gershanik
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Abstract
A self-emulsifying oily formulation (SEOF) comprising an oil component and a surfactant, the SEOF being characterized in that the oil component comprises an oily carrier and a cationic lipid and optionally, a lipophilic oily fatty alcohol, the oil-in-water emulsion which forms upon mixture of the SEOF, having oily droplets which are positively charged.
Claims22
A pharmaceutical composition comprising an orally administered drug which is either hydrophobic or of limited aqueous solubility and a self-emulsifying oily formulation (SEOF), said SEOF comprising an oily component and a surfactant,
- said SEOF being characterized in that the oily component comprises an oily carrier, a cationic lipid and a lipophilic oily fatty alcohol, the oil-in-water emulsion which is formed by mixing the SEOF with an aqueous solution having positively charged oily droplets,
- said oily carrier being one or more selected from the group consisting of a medium chain triglyceride oil (MCT) in which the hydrocarbon chain has an average chain length of 8 to 12 carbon atoms, a long chain triglyceride oil (LCT) in which the hydrocarbon chain has an average chain length of more than 12 carbon atoms, and an oily fatty acid derivative.
A method for the administration of an orally administered drug which is either hydrophobic or of limited aqueous solubility to a subject comprising administrating said drug in a self-emulsifying oily formulation (SEOF), said SEOF comprising an oily component and a surfactant,
- the SEOF being characterized in that the oily component comprises an oily carrier, a cationic lipid and a lipophilic oily fatty alcohol, the oil-in-water emulsion which is formed by mixing the SEOF with an aqueous solution having positively charged oily droplets,
- said oily carrier being one or more selected from the group consisting of a medium chain triglyceride oil (MCT) in which the hydrocarbon chain has an average chain length of 8 to 12 carbon atoms, a long chain triglyceride oil (LCT) in which the hydrocarbon chain has an average chain length of more than 12 carbon atoms, and an oily fatty acid derivative.
A process for the production of an emulsion which comprises mixing an SEOF with an aqueous solution, wherein said SEOF comprises an orally administered drug which is either hydrophobic or of limited aqueous solubility, an oily component and a surfactant,
- the SEOF being characterized in that the oily component comprises an oily carrier, a cationic lipid and a lipophilic oily fatty alcohol, the oil-in-water emulsion which is formed by mixing the SEOF with said aqueous solution having positively charged oily droplets, said oily carrier being one or more selected from the group consisting of a medium chain triglyceride oil (MCT) in which the hydrocarbon chain has an average chain length of 8 to 12 carbon atoms, a long chain triglyceride oil (LCT) in which the hydrocarbon chain has an average chain length of more than 12 carbon atoms, and an oily fatty acid derivative.
Dependencies are inferred from the claim text.