Immunity to trypanosomatids species
OwnerNicolas Joseph Fasel, Theresa Ann Glaserinventors
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Abstract
The present invention relates to trypanosomatid histones in substantially isolated form for use as a protective antigen against trypanosomatid infection. These histones may be either isolated from the corresponding parasite or be produced by means of recombinant DNA techniques. For the latter purpose the invention also provides genes encoding histones and derivatives of the genes like other nucleic acids and gene products like peptides and proteins. The invention further provides diagnostic tests, pharmaceutical compositions and vaccines comprising the usual excipients and/or adjuvants and at least one histone, a histone encoding gene or a derivative thereof.
Claims14
Leishania gone encoding a histone polypeptide, said polypeptide having protective capacity against leishmaniasis, and said gene having a nucleotide sequence that specifically hybridizes with:
- a) those portions of the sequence depicted in FIG. 6A (SEQ ID NO:4) that are protective with respect to a Leishmania organism;
- b) those portions of the sequence of FIG. 6A (SEQ ID NO:4) that encode a part/parts of the histone that is/are protective with respect to a Leishmania organism;
- or
- c) a complementary strand of (either a) or b).
Dependencies are inferred from the claim text.