Epitopic regions of pneumococcal surface protein a
AssigneeThe UAB Research Foundation
InventorsDavid E. Briles, Janet L. Yother, Larry S. McDaniel, Hong-Yin Wu
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Abstract
A region of the PspA protein of the Rx1 strain of Streptococcus pneumoniae has been identified as containing protection-eliciting epitopes which are cross-reactive with PspAs of other S. pneumoniae strains and which is cross-protective. The region comprises the 68-amino acid sequence extending from amino acid residues 192 to 260 of the Rx1 PspA strain.
Claims35
An isolated, truncated pneumococcal surface protein A (PspA) fragment comprising amino acid residues 192 to 588 or 167 to 588 of PspA of Streptococcus pneumoniae and containing at least one protection-eliciting epitope.
An isolated polypeptide comprising at least one protection-eliciting epitope contained in amino acid residues 167 to 588 pneumococcal surface protein A of Streptococcus pneumoniae.
An isolated polypeptide comprising at least one protection-eliciting epitope contained in amino acid residues 192 to 588 of pneumococcal surface protein A of Streptococcus pneumoniae.
An isolated pneumococcal surface protein A (PspA) fragment consisting essentially of a C-terminal portion of the PspA protein from amino acid residue 167 or 192 up to and including the amino acid residue 588 and containing at least one protection-eliciting epitope.
A tandem protein fragment comprising a plurality of conjugated molecules, said molecules comprising an isolated pneumococcal surface protein A (PspA) protein fragment corresponding to the amino acid sequence of at least one protection-eliciting epitope located in residues 167 or 192 to 588 of the PspA, each molecule within said plurality of conjugated molecules being derived from different strains of Streptococcus pneumoniae.
Dependencies are inferred from the claim text.