Bone resorption assay
OwnerDavid J. Baylinkinventor
Life of this patent
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Abstract
Compositions and methods are provided which are useful in determining the levels of the C-telopeptide of human Type I collagen. The levels of the C-telopeptide are used as a marker of collagen degradation in an individual, and thus serve as a sensitive and specific indicator of bone resorption. Assays for the C-telopeptide find a variety of uses, including use in diagnosing metabolic bone disorders such as osteoporosis or postmenopausal rapid bone losers, monitoring the efficacy of therapeutic regimens designed to treat such disorders, determining the extent of imbalances between bone formation and resorption.
Claims7
A recombinant or synthetic peptide having from six to fifty amino acids and which has an epitope contained within the sequence Asp-Phe-Ser-Phe-Leu-Pro-Gln-Pro-Pro-Gln-Glu-Lys-Ala-His-Asp-Gly-Gly-Arg (SEQ ID NO:1), wherein said peptide lacks hydroxylysyl pvridinoline crosslinks or lysyl pyridinoline crosslinks, and wherein said peptide immunologically competes with the C-telopeptide of type I collagen.
Dependencies are inferred from the claim text.