Back to results
US 5,965,109 AGranted
Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
AssigneeMolecular Biosystems, Inc.
InventorRolf Lohrmann
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for making insoluble gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell, and products of this process. This barrier serves to decrease the rate of gas exchange between the microsphere and the aqueous environment surrounding the microsphere and thus enhances resistance to pressure due to gas exchange.
Claims14
A process for making gas-filled, pressure-resistant microspheres having a shell and a hydrophobic barrier contained within said shell comprising:
- (a) saturating an insoluble gas with a hydrophobic compound having a boiling point above room temperature;
- (b) mixing said saturated gas with a solution of a microsphere shell material at a temperature above room temperature;
- (c) forming microspheres by cavitation;
- and
- (d) cooling said microspheres below said boiling point to cause said hydrophobic compound to condense and form a hydrophobic barrier.
2 more elements
Dependencies are inferred from the claim text.