Technetium-99m labeled peptides for imaging
AssigneeDiatide, Inc.
InventorsRichard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Abstract
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.
Claims8
A complex formed by reacting technetium-99m and a reducing agent with a reagent comprising
- a) a peptide that specifically binds to a target in vivo;
- and
- b) a radiolabel binding moiety covalently linked to the peptide;
- wherein the complex between said technetium-99m and said moiety is electrically neutral, avoiding interference by the complex with specific binding of the peptide to the target.
A complex formed by labeling a reagent comprising
- a) a peptide that specifically binds to a target in vivo;
- and
- b) a radiolabel binding moiety covalently linked to the peptide;
- with technetium-99m by ligand exchange of a prereduced technetium-99m complex, wherein the complex between said technetium-99m and said moiety is electrically neutral, avoiding interference by the complex with specific binding of the pettide to the target.
An electrically neutral complex formed between technetium-99m and a radiolabel-binding moiety covalently linked to a peptide having specific binding properties, wherein interference with said properties by said complex is avoided.
Dependencies are inferred from the claim text.