US 5,965,088 AGranted

Method for providing rapid disinfection of contact lenses

OwnerAndrea M. Lever, O. William Lever, Jr.inventors

Life of this patent

Estimating the term…

Loading patent…

Abstract

The present invention is directed to method of disinfecting a contact lens with an ophthalmically safe disinfecting aqueous solution comprising about 2.0 to about 8.0 ppm of a bis(biguanide) having the following formula: ##STR1## wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, ether or thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alky radical having 5-12 carbon atoms; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12, carbon atoms; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the group consisting of a divalent alkyl, alkyloxyalkyl, or alkylsufide radical each having 4-12 carbon atoms. The invention is also directed to a method of cleaning and/or disinfecting a contact lens within a minimum soaking period that is not more than about 75 minutes.

Claims20

Dependent claims

A method of cleaning and/or disinfecting a soft contact lens comprising:

(a) rubbing the contact lens with an ophthalmically safe solution comprising the following components:
(i) a microbiocidally effective amount of the hydrorhloride salt of a bis(biguanide) in the amount of about 2.0 to about 8.0 ppm, or a corresponding molar amount of the bis(biguanide) in the form of another water-soluble salt or the free base thereof, which bis(biguanide) has the following general formula:
##STR13## wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, alkoxyalkyl ether or alkylsulfide thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl radical having 5-12 carbon atoms;
R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12 carbon atoms;
R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is a divalent group having 4-16 carbon atoms and is selected from the group consisting of alkylene, alkyloxyalkyl, and alkylsufide radical, wherein the aforesaid alkyoxyalkyl or alkylsulfide radicals are either a polymethylene chain interrupted with one or more oxygen and/or sulfur atoms or a polymethylene chain substituted with an alkoxy (--OR.sup.8) or alkylthio (--SR.sup.9) group, wherein R.sup.8 and R.sup.9 are independently selected from the group consisting of alkyl having 1-12 carbon atoms, or a cycloalkyl or cycloalkyl-alkyl having 5-12 carbon, or wherein A is a divalent polymethylelne group having 8 to 16 carbon atoms interrupted with a divalent radical of cyclohexane or diaza-cyclohexane;
(ii) an effective amount of a buffering agent,
(iii) an effective amount of a surfactant;
and
(b) soaking the rubbed contact lens from step (a) in the solution for a total period of time that is within a range of about 5 minutes to about 75 minutes;
and
(c) directly placing the treated lens on an eye of the wearer, such that a rinse with a different solution is not required.

8 more elements

A method of cleaning and/or disinfecting a contact lens comprising:

(a) rubbing the contact lens with an ophthalmically safe solution comprising the following components:
(i) microbiocidally effective amount of the hydrochloride salt of a bis(biguanide) in the amount of about 2.0 to about 8.0 ppm, or a corresponding molar amount of the bis(biguanide) in the form of another water-soluble salt or the free base thereof, which bis(biguanide) has the following general formula:
##STR15## wherein wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, alkoxyalkyl or alkylsulfide radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl radical having 5-12 carbon atoms;
R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12 carbon atoms;
R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is a divalent group having 4-16 carbon atoms and is selected from the group consisting of an alkylene, alkyloxyalkyl, and alkylsufide radical, wherein the aforesaid alkyoxyalkyl or alkylsulfide radicals are either a polymethylene chain interrupted with one or more oxygen and/or sulfur atoms or a polymethylene chain substituted with an alkoxy (--OR.sup.8) or alkylthio (--SR.sup.9) group, wherein R.sup.8 and R.sup.9 are independently selected from the group consisting of alkyl having 1-12 carbon atoms, or a cycloalkyl or cycloalkyl-alkyl having 5-12 carbon, or wherein A is a divalent polymethylene group having 8 to 16 carbon atoms interrupted with a divalent radical of cyclohexane or diaza-cyclohexane;
(ii) one or more polymeric biguanides in the total amount of about 0.1 to about 3.0 ppm, which polymeric biguanides have the following formula:
##STR16## wherein Z is an organic divalent bridging group which may be the same or different throughout the polymer, n is at least 3, and X.sup.1 and X.sup.2 are independently selected from the groups --NH.sub.2 and ##STR17## (iii) an effective amount of a buffering agent;
(iv) an effective amount of a surfactant present;
and
(b) soaking the rubbed contact lens from step (a) in the solution for a total period of time that is within a range of about 5 minutes to about 75 minutes;
and
(c) directly placing the treated lens on an eye of the wearer, such that a rinse with a different solution is not required.

9 more elements

Dependencies are inferred from the claim text.