.alpha.-hydrazino acid derivatives and method for making same
AssigneeCentre National De La Recherche Scientifique
InventorsAndre Collet, Joelle Vidal, Jean-Christophe Hannachi, Laure Guy
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Abstract
An .alpha.-hydrazino acid derivative of general formula (I) is described, wherein R.sub.1, R.sub.2, R.sub.3 are hydrogen or a carbon radical, such that when R.sub.2 and R.sub.3 are different, C* is an asymmetric carbon of L, D or DL configuration, and R.sub.4 and R.sub.5 are a protecting group, characterized in that R.sub.4 is a benzyl ArCH.sub.2 radical of formula (a), wherein Ar is a phenyl radical or phenyl substituted by one or more X groups; X being hydrogen, halogen, a nitro or alkyl radical; and in that R.sub.5 is a Y--O--CO group, where Y is a carbon radical different from R.sub.4.
Claims8
An .alpha.-hydrazino acid derivative of general formula:
- ##STR23## in which:
- R.sub.1, R.sub.2 and R.sub.3 denote hydrogen or a radical comprising at least one carbon atom,
- while R.sub.2 and R.sub.3 are different, C* denotes an asymmetric carbon of L, D or DL configuration,
- R.sub.4 and R.sub.5 denote a protecting group,
- wherein:
- R.sub.4 denotes a benzyl radical ArCH.sub.2 of formula:
- ##STR24## where Ar denotes a phenyl radical or a phenyl radical substituted with one or more groups X;
- where X denotes hydrogen, a halogen, a nitro radical or an alkyl radical;
- and R.sub.5 denotes a tert-butoxycarbonyl (Boc).
An .alpha.-hydrazino acid derivative of general formula:
- ##STR25## in which:
- R.sub.1, R.sub.2 and R.sub.3 denote hydrogen or a radical comprising at least one carbon atom,
- while R.sub.2 and R.sub.3 are different, C* denotes an asymmetric carbon of L, D or DL configuration,
- R.sub.4 and R.sub.5 denote a protecting group,
- wherein:
- R.sub.4 denotes a benzyl radical ArCH.sub.2 of formula:
- ##STR26## where Ar denotes a phenyl radical or a phenyl radical substituted with one or more groups X;
- where X denotes hydrogen, a halogen, a nitro radical or an alkyl radical;
- and R.sub.5 denotes a 9-fluorenylmethoxycarbonyl (Fmoc).
Dependencies are inferred from the claim text.