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US 5,962,684 AGranted
Method of preparation of dideoxycarbocyclic nucleosides
AssigneeRegents of the University of Minnesota
InventorsRobert Vince, Mei Hua
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Abstract
A therapeutic method is provided, employing an antiviral compound of the general formula: ##STR1## wherein Z is H, OR' or N(R).sub.2, wherein R' is H, (C.sub.1 -C.sub.4)alkyl, aryl, CHO, (C.sub.1 -C.sub.16)alkanoyl or O.dbd.P(OH).sub.2, Y is CH or N, and X is selected from the group consisting of H, N(R).sub.2, SR, OR' or halogen, wherein R is H, lower(C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.
Claims9
A method of preparing a compound of formula (I):
- ##STR9## wherein Y is CH, Z is H or NH.sub.2 and X is monosubstituted amino or disubstituted amino, comprising:
- (a) reacting a compound of formula (II):
- ##STR10## wherein X is halo, Z is H or NH.sub.2 and Y is CH with a monosubstituted amine or a disubstituted amine to yield said compound of formula (I).
Dependencies are inferred from the claim text.