Antisense modulation of inhibitor-kappa B kinase-alpha expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Inhibitor-kappa B Kinase-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Inhibitor-kappa B Kinase-alpha. Methods of using these compounds for modulation of Inhibitor-kappa B Kinase-alpha expression and for treatment of diseases associated with expression of Inhibitor-kappa B Kinase-alpha are provided.
Claims20
An antisense compound 8 to 30 nucleobases in length targeted to SEQ ID NO:
- 1, wherein said antisense compound inhibits the expression of human Inhibitor-kappa B Kinase-alpha.
An antisense compound up to 30 nucleobases in length comprising SEQ ID NO:
- 8, 10, 12, 14, 20, 26, 27, 34, 35, 37, 38, 43, 44, or 45 which inhibits the expression of human Inhibitor-kappa B Kinase-alpha.
Dependencies are inferred from the claim text.