Antisense modulation of RhoB expression
AssigneeIsis Pharmaceuticals, Inc.
InventorLex M. Coswert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of RhoB. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RhoB. Methods of using these compounds for modulation of RhoB expression and for treatment of diseases associated with expression of RhoB are provided.
Claims12
An antisense compound 8 to 30 nucleobases in length targeted to SEQ ID NO:1, wherein said antisense compound inhibits the expression of human RhoB.
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 10, 11, 12, 14, 15, 16, 18, 19, 20, 21, 23, 24, 25, 26, 27, 29, 30, 31, 33, 34, 35, 40, 42, 43, 46 or 47 which inhibits the expression of human RhoB.
Dependencies are inferred from the claim text.