Antiproliferative factor from patients with interstitial cystitis
AssigneeUniversity of Maryland
InventorsSusan Keay, John W. Warren, Michael Kleinberg, Michael K. Hise
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Abstract
A novel antiproliferative factor (APF) present in urine of patients with interstitial cystitis (IC) is described. This urine antiproliferative factor can serve as a marker for disease activity and its antagonists as therapeutic medicaments for IC. In addition, APF and its agonists can be used for treating diseases associated with cell proliferation.
Claims4
Purified human antiproliferative factor (APF), said factor being isolated from the urine of patients with interstitial cystitis wherein said factor is characterized by a molecular weight of about 1.7 kDa determined by mass spectrometry on a sample in an aqueous acetonitrile solution and a pI range of about 1.38-3.5, said factor capable of inhibiting normal bladder epithelial (HBE) and bladder carcinoma cell proliferation.
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