Integrin .beta. subunit and uses thereof
AssigneesThe Regents of the University of California, The Scripps Research Institute
InventorsDean Sheppard, Vito Quaranta, Robert Pytela
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Abstract
The present invention provides substantially pure integrins containing a novel .beta. subunit designated as .beta..sub.6. The novel .beta..sub.6 subunit forms heterodimers with .alpha..sub.V and .alpha..sub.F. Methods of controlling cell adhesion using the B.sub.6 -containing integrins are also provided.
Claims3
A substantially purified integrin cell surface receptor subunit comprising .beta..sub.6 having the amino acid sequence set forth in FIG. 3 for human.
A substantially purified integrin comprising .beta..sub.6 bound to an .alpha. subunit, wherein the .beta..sub.6 subunit has the amino acid sequence set forth in FIG. 3 for human.
Dependencies are inferred from the claim text.