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US 5,962,638 AGranted
Peptides and synthetic cell membranes
AssigneeMerck Patent GmbH
InventorsRenate Naumann, Alfred Jonczyk
Life of this patent
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Abstract
Linear peptides of the formula (I) R-A-B-C-D-E-OH, where R, A, B, C, D and E have the indicated meanings, are disclosed. Methods of making these peptides, and of using them as biosensors, solar cells and membrane models for use in the investigation of biochemical processes are disclosed.
Claims16
A peptide or modified peptide of formula I
- R-A-B-C-D-E-OH I,
- in which
- A is an amino acid residue selected from a group consisting of Ala, Gly and Leu,
- B is an amino acid or dipeptide residue selected from a group consisting of Ala, Ser, Gly-Gly and Ser-Ser,
- C is a residue selected from a group consisting of Ala, Ala-Ala, Leu-Leu, Ala-Ala-Ala, Arg-Gly-Asp and Leu-Leu-Leu,
- D is an amino acid residue selected from a group consisting of Ala and Ser,
- E is an amino acid or dipeptide residue selected from a group consisting of Ala, Leu and Pro-Lys,
- R is HS-alkyl-CO, HS-alkyl-CO-NH-alkyl'-CO-, Trt-S-alkyl-CO-, Trt-S-alkyl-CO-NH-alkyl'-CO- or 1,2-dithiocyclopentane-3-(CH.sub.2).sub.4 --CO-,
- alkyl and alkyl' are each, independently of one another, an alkylene radical with 1 to 11 C atoms
- and
- Trt is triphenylmethyl, and the salts thereof.
8 more elements
Dependencies are inferred from the claim text.