Therapeutic compounds
AssigneesBiomolecular Research Institute Ltd., MacFarlane Burnet Centre For Medical Research Ltd.- Fairfield Hospital, Commonwealth Scientific and Industrial Research Organisation
InventorsAhmed Abdullah Azad, Cyril C Curtain, Alison Louise Greenway, Dale Alan McPhee, Ian MacReadie
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Abstract
A biologically-active peptide fragment of the Nef protein of human immunodeficiency virus is provided, pharmaceutical compositions comprising the peptide, analogs or derivatives of the peptide and therepeutic and screening methods which utilize the peptide and compositions which comprise them. The invention is particularly useful in the suppression of the immnune respons or in the suppression of symptoms of autoimmune disease.
Claims20
A substantially pure immunosuppressive peptide, said peptide corresponding to amino acids 2-19 of the N-terminal sequence of Nef, or an immunosuppressive analogue or derivative thereof.
A substantially pure immunosuppressive peptide, said peptide corresponding to amino acids 2-22 of the N-terminal sequence of Nef, or an immunosuppressive analogue or derivative thereof.
Dependencies are inferred from the claim text.