Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery
AssigneeEuropean Community
InventorsChristian Grandfils, Robert Jerome, Nicole Nihant, Philippe Teyssie
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Abstract
The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a polyether, a lipophilic or polypeptide drug and a biocompatible cholesterol interacting agent for preserving the activity of the drug administered to the patient while at the same time controlling the release of the drug. Methods for making the homogeneous drug delivery nanoparticles are also disclosed.
Claims11
Nanoparticles for proteinaceous drugs or peptides with a homogenous particle size between 50 and 200 nm, containing:
- (a) a biocompatible polymer selected from the group consisting of poly.epsilon.caprolactone, polylactide, polyglycolide, and copolymers thereof,
- (b) a biocompatible interacting agent selected from the group consisting of polyethyleneglycol, and polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer having the general formula
- HO(C.sub.2 H.sub.4 O).sub.a (C.sub.3 H.sub.6 O).sub.b (C.sub.2 H.sub.4 O).sub.a H
- wherein a and b are selected to give a number-average molecular weight of the total interacting agent in the range of some hundreds to 20,000 Da, or an amphilic graft copolymer containing a hydrophilic backbone grafted with hydrophobic aliphatic polyester subchains,
- (c) a cholesterol or anionic cholesterol derivative as a biocompatible surfactant, and
- (d) a low molecular lipophilic compound and/or a polypeptide as a drug,
- wherein (a), (b), (c) and (d) form a homogeneously mixed blend.
Dependencies are inferred from the claim text.