Bioactive composite material for repair of hard and soft tissues
AssigneesUniversity of London, University of Florida Research Foundation, Inc.
InventorsWilliam Bonfield, Min Wang, Larry L. Hench
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Abstract
Composites suitable for use as prostheses for attachment to soft tissues, such as cartilage, tendons, skin, tympanic membrane and gingiva, as well as to cancellous or trabecular bone, are based on combination of a polyolefinic binder with certain bioactive glass materials. The composites bond actively with soft tissues and are readily formulated achieve mechanical properties comparable to those of the soft tissue of interest.
Claims6
A prosthesis for the replacement of or attachment to soft tissue, cancellous bone or cartilage formed by compounding, in the solid phase, a homo or copolyolefin binder with an effective amount of particulate bioactive glass material to form a composite, said particulate bioactive glass including an effective amount of cationic metal oxide, Si, and P to form a silica rich layer followed by formation of hydroxyapatite in vivo the composite being capable of bonding with, and exhibiting a Young's modulus comparable to, a soft tissue.
A prosthesis for the replacement of or attachment to cancellous bone or cartilage formed by compounding, in the solid phase, a homo- or copolyolefin binder with an effective amount of particulate bioactive glass material to form a composite, the composite being capable of bonding with, and exhibiting a Young's modulus comparable to, a soft tissue wherein said particulate bioactive glass includes SiO.sub.2 of 42% to 52% by weight of the particulate bioactive glass, said prosthesis having a glass loading fraction of 5% to 50% by volume, and said particulate bioactive glass including particles of 0.05 .mu.m to 500 .mu.m.
A prosthesis comprising composite material including a solid-phase homo- or copolyolefin binder having dispersed therein an effective amount of particulate bioactive glass of 42% to 52% by weight SiO.sub.2, including particles of a size of 0.05 .mu.m to 500 .mu.m and a glass loading fraction of 5% to 50% by volume.
Dependencies are inferred from the claim text.