Metalloproteinase inhibitors

A compound of formula (II) ##STR44## wherein R.sub.1 is selected from the group consisting of (C.sub.1 -C.sub.6)alkyl, (C.sub.2 -C.sub.6)alkenyl, phenyl, substituted phenyl, phenyl(C.sub.1 -C.sub.6)alkyl, substituted phenyl(C.sub.1 -C.sub.6)alkyl, amino(C.sub.1 -C.sub.6)alkyl;

• hydroxy-(C.sub.1 -C.sub.6)alkyl, mercapto(C.sub.1 -C.sub.6)alkyl and carboxy(C.sub.1 -C.sub.6)alkyl wherein the amino-, hydroxy-, mercapto-, or carboxyl-group is optionally protected or the carboxyl-group amidated;
• R.sub.2 represents (i) a group Z.sup.1 --Q--W--, or (ii) (Z.sup.1 --Q--W--).sub.2 CH-- in which each of the two groups Z.sup.1 --Q--W-- present may be the same or different, and wherein in both cases (i) and (ii):
• Z.sup.1 represents hydrogen or an optionally substituted aryl, cycloalkyl, or cycloalkenyl group, and
• --Q--W-- taken together represent a bond, or
• Q represents a bond or --O-- or --S-- and W represents a divalent C.sub.1 -C.sub.20 straight or branched alkyl or C.sub.2 -C.sub.20 alkenyl group which
• (a) may be interrupted by one or more non-adjacent ether or thioether linkages or --N(R.sub.x)-- groups wherein R.sub.x is hydrogen, or C.sub.1 -C.sub.6 alkyl, and/or
• (b) may carry one or more substituents selected from the group consisting of --OH, --SH, --O(Alk), --S(Alk), halogen, --NH2, --NH(Alk), --N(Alk).sub.2, --CO.sub.2 H, --CO.sub.2 (Alk), --CO(Alk), --CHO, --CHONH.sub.2, --CONH(Alk), --CON(Alk).sub.2, --(Alk)OH, --(Alk)SH, and --NHCO(Alk) where Alk represents C.sub.1 -C.sub.6 alkyl;
• z represents a group Z.sup.1 --Q--W-- wherein Z.sup.1 represents hydrogen or an optionally substituted cycloalkyl, or cycloalkenyl group and Q represents a bond or --O-- or --S-- and W represents a bond or --O-- or --S-- and W represents a divalent C.sub.1 -C.sub.20 straight or branched alkyl or C.sub.2 -C.sub.20 alkenyl group which
• (a) may be interrupted by one or more non-adjacent ether or thioether linkages or --N(R.sub.x)-- groups wherein R.sub.x is hydrogen, or C.sub.1 -C.sub.6 alkyl, and/or
• (b) may carry one or more substituents selected from the group consisting of --OH, --SH, --O(Alk), --S(Alk), halogen, --NH.sub.2, --NH(Alk), --N(Alk).sub.2, --CO.sub.2 H, --CO.sub.2 (Alk), --CO(Alk), --CHO, --CHONH.sub.2, --CONH(Alk), --CON(Alk).sub.2, --(Alk)OH, --(Alk)SH, and --NHCO(Alk) where Alk represents C.sub.1 -C.sub.6 alkyl;
• or a salt, hydrate or solvate thereof.