6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same
AssigneeSigma-Tau
InventorsPiero Foresta, Mauro Marzi, Maria Ornella Tinti
Life of this patent
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Abstract
6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.
Claims5
A pharmaceutical composition of 2-N-propylamino-6,7-diacetoxytetraline having immunomodulating effect in a patient immunosuppressed by an alkylating agent and a pharmaceutically acceptable excipient thereof.
The method of stimulating the immune system of a patient immunosuppressed by an alkylating agent which comprises orally or parenterally administering to the patient an effective amount of a 6,7-disubstituted-2-aminotetraline of formula (1) ##STR7## and its pharmacologically acceptable salts, wherein X and Y, identical or different, are selected from the group consisting of methoxy, acetoxy, and fluoro;
- and R and R1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3(4-methoxyphenoxy)propyl.
Dependencies are inferred from the claim text.