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US 5,962,523 AGranted
Methods of using butyric acid derivatives to protect against hair loss
AssigneeDiscovery Laboratories, Inc.
InventorsS. Mark Moran, Thomas R. Alessi
Life of this patent
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Abstract
The present invention relates to methods of protecting against injury to hair follicles in a mammal by administering an effective amount of butyric acid or a biologically active butyric acid derivative. In particular, this invention relates to the use of cell differentiation-inducing butyric acid derivatives to protect against hair loss in cancer patients undergoing chemotherapy and/or radiation therapy.
Claims18
A method of protecting against injury to hair follicles in a subject, comprising:
- administering to the subject an effective amount of a compound having the structure of:
- ##STR8## wherein:
- W.sup.1, W.sup.2 and W.sup.3 each independent from the other represents H, F, Br, Cl or I;
- X.sup.1 and X.sup.2 each independent from the other represents H, F, Br, Cl, I, methyl, CF.sub.3 ;
- Y.sup.1 and Y.sup.2 each independent from the other represents H, F, Br, Cl, I, methyl, CF.sub.3, ethyl or perfluoroethyl;
- Z represents O;
- and
- A represents or Q--CHR.sup.4 --O--C(.dbd.O)R.sup.5 where Q represents a covalent bond or an alkyl;
- R.sup.4 represents H or an alkyl;
- and R.sup.5 represents alkyl or ##STR9## a pharmaceutically acceptable salt or prodrug thereof;
- and wherein said effective amount protects the subject against hair loss.
8 more elements
Dependencies are inferred from the claim text.