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US 5,962,495 AGranted
Selective aromatase inhibiting compounds
AssigneeRisto Arvo Sakari Lammintausta
InventorsArto Johannes Karjalainen, Marja-Liisa Sodervall, Arja Marketta Kalapudas, Reino Olavi Pelkonen, Aire Marja Laine, Risto Arvo Sakari Lammintausta, Jarmo Sakari Salonen
Life of this patent
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Abstract
The abstract isn’t available for this document.
Claims10
A compound of formula:
- ##STR21## wherein R.sub.1 is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CN, CF.sub.3, CHF.sub.2, CH.sub.2 F or halogen;
- R.sub.2 is 1-imidazolyl, R.sub.3 is H or OH, R.sub.5 is H or OH;
- R.sub.6 is methylene, ethylene, --CHOH--, --CH.sub.2 --CHOH--, or --CHOH--CH.sub.2 --;
- or
- a stereoisomer thereof;
- or
- a non-toxic pharmaceutically acceptable acid addition salt thereof;
- with the proviso that when R.sub.3 and R.sub.5 are H, R.sub.6 cannot be methylene or ethylene.
5 more elements
A compound of formula:
- ##STR22## wherein R.sub.1 is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CF.sub.3, CHF.sub.2, CH.sub.2 F, or halogen, R.sub.2 is 1-imidazolyl, R.sub.3 is H or OH, R.sub.5 is H or OH;
- R.sub.6 is methylene, ethylene, --CHOH--, --CH.sub.2 --CHOH--, or --CHOH--CH.sub.2 --;
- or
- a stereoisomer thereof;
- or
- a non-toxic pharmaceutically acceptable acid addition salt thereof;
- with the proviso that when R.sub.3 and R.sub.5 are H, R.sub.6 cannot be methylene or ethylene.
4 more elements
A compound of formula:
- ##STR23## wherein R.sub.1 is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CN, CF.sub.3, CHF.sub.2, CH.sub.2 F, or halogen, R.sub.2 is 1-imidazolyl, R.sub.3 is H or OH, R.sub.5 is H or OH;
- R.sub.6 is --CHOH--, --CH.sub.2 --CHOH--, or --CHOH--CH.sub.2 --;
- or
- a stereoisomer thereof;
- or
- a non-toxic pharmaceutically acceptable acid addition salt thereof;
- with the proviso that when R.sub.3 and R.sub.5 are H, R.sub.6 cannot be methylene or ethylene.
4 more elements
Dependencies are inferred from the claim text.