2-mercaptobenzimidazole derivatives and antihyperlipemic agent or antiarteriosclerotic agent containing the same
AssigneeFuji Photo Film Co., Ltd.
InventorsKozo Aoki, Kazuhiro Aikawa
Life of this patent
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Abstract
2-Mercaptobenzimidazole derivatives represented by the following formulae, analogs and salts thereof are disclosed: ##STR1## These 2-mercaptobenzimidazole derivatives are useful as a medicine such as an antihyperlipemic agent or antiarteriosclerotic agent and also useful as an additive for silver halide photosensitive materials, liquid crystals and the like.
Claims10
A method for inhibiting hyperlipemia or atherosclerosis comprising administering an effective amount of a 2-mercaptobenzimidazole compound represented by formula IV:
- ##STR13## wherein R.sub.3 and R.sub.4 each represent a hydrogen atom, a halogen atom, or an alkyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfamoyl, acylamino, sulfonylamino, cyano or nitro group;
- R.sub.50 and R.sub.60 each represent a hydrogen atom, alkyl group, or acyl group;
- n.sub.3, n.sub.4, each represent 1 or 2;
- and
- L.sub.2 represents a connecting group which is an alkylene group or a phenylene group-containing an alkylene group, or
- a pharmaceutically acceptable salt thereof, to a mammal.
A method for therapy of hyperlipemia or atherosclerosis in a mammal comprising administering an effective amount of a 2-mercaptobenzimidazole compound represented by formula IV:
- ##STR15## wherein R.sub.3 and R.sub.4 each represent a hydrogen atom, halogen atom, or alkyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfamoyl, acylamino, sulfonylamino, cyano or nitro group;
- R.sub.50 and R.sub.60 each represent a hydrogen atom, alkyl group, or acyl group;
- n.sub.3, n.sub.4 each represent 1 or 2;
- and,
- L.sub.2 represents a connecting group which is an alkylene group or phenylene group-containing alkylene group, or
- a pharmaceutically acceptable salt thereof, to a mammal.
A method for inhibiting foamy macrophages in a mammal comprising contacting a foamy macrophage with an effective amount of a 2-mercaptobenzimidazole compound represented by formula IV:
- ##STR16## wherein R.sub.3 and R.sub.4 each represent a hydrogen atom, a halogen atom, or an alkyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfamoyl, acylamino, sulfonylamino, cyano or nitro group;
- R.sub.50 and R.sub.60 each represent a hydrogen atom, alkyl group, or acyl group;
- n.sub.3, n.sub.4 each represent 1 or 2;
- and
- L.sub.2 represents a connecting group which is an alkylene group or a phenylene group-containing an alkylene group, or
- a pharmaceutically acceptable salt.
A method for reducing the formation of cholesteryl ester in foamy macrophages in a mammal comprising contacting a foamy macrophage with an effective amount of a 2-mercaptobenzimidazole compound represented by formula IV:
- ##STR17## wherein R.sub.3 and R.sub.4 each represent a hydrogen atom, a halogen atom, or an alkyl, alkoxy, alkoxycarbonyl, carbamoyl, sulfamoyl, acylamino, sulfonylamino, cyano or nitro group;
- R.sub.50 and R.sub.60 each represent a hydrogen atom, alkyl group, or acyl group;
- n.sub.3, n.sub.4 each represent 1 or 2;
- and
- L.sub.2 represents a connecting group which is an alkylene group or a phenylene group-containing an alkylene group, or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.