Trisubstituted phenyl derivatives and processes for their preparation

A pharmaceutical composition comprising a compound of formula (1):

• ##STR10## wherein Y is a halogen atom or a group --OR.sup.1, where R.sup.1 is an optionally substituted alkyl group;
• X is --O--, --S--, or --N(R.sup.7)--, where R.sup.7 is a hydrogen atom or an alkyl group;
• R.sup.2 is an optionally substituted cycloalkyl or cycloalkenyl group;
• R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or an alkyl, --CO.sub.2 R.sup.8 (where R.sup.8 is a hydrogen atom or an optionally substituted alkyl, aryl, or aralkyl group), --CONR.sup.9 R.sup.10 (where R.sup.9 and R.sup.10 which may be the same or different is each a hydrogen atom or an alkyl, aryl or aralkyl group), --CSNR.sup.9 R.sup.10, --CN, or --CH.sub.2 CN group;
• Z is --(CH.sub.2).sub.n -- where n is zero or an integer 1, 2 or 3;
• R.sup.5 is an optionally substituted monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms;
• R.sup.6 is a hydrogen atom or a hydroxyl group;
• or a salt, solvate, hydrate, prodrug or N-oxide thereof, together with one or more pharmaceutically acceptable carriers, excipients or diluents;
• with the provisos that R.sup.5 is other than an optionally substituted 4-pyridyl group and when Y is --OCH.sub.3, X is --O--, R.sup.2 is unsubstituted C.sub.3-7 cycloalkyl, R.sup.3 and R.sup.4 are hydrogen and R.sup.5 is unsubstituted phenyl or phenyl substituted with halogen, hydroxyl, acetoxy, amino or acetamido, then R.sup.6 is hydrogen.