Cyclic nitrones
AssigneeHoechst Marion Roussel, Inc.
InventorsCraig E. Thomas, Thomas L. Fevig, Stephen M. Bowen, Robert A. Farr, Albert A. Carr, David A. Janowick
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Abstract
The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositions containing these cyclic nitrones.
Claims16
The compound which is 2,2-dimethyl-1,2-dihydrobenzof!isoquinoline N-oxide.
The compound which is 3,3-dimethyl-3,4-dihydrobenzoisoh!quinoline N-oxide.
The compound which is 5,5-dimethyl-4,5-dihydrothieno2,3-c!pyridine N-oxide.
The compound which is 5,5-dimethyl-4,5-dihydrofuro2,3-c!pyridine N-oxide.
The compound which is 6,6-dimethyl-6,7-dihydrothieno3,2-c!pyridine N-oxide.
A compound which is 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide.
A compound which is 4-acetoxy-3,3-dimethyl-3,4-dihydroisoquinoline N-oxide.
A compound which is 3,3-dimethyl-3H-isoquinoline-4-one N-oxide.
Dependencies are inferred from the claim text.