Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein
AssigneeMassachusetts Institute of Technology
InventorsRoger M. Nitsch, Richard J. Wurtman
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Abstract
Stimulating non-amyloidogenic processing by the activation of cell surface serotonin receptors linked to phospholipase and protein kinase C is described. Activation of the cell surface serotonin receptors is accomplished by contacting the cell with an agent which is a serotonin agonist or which increases the intrasynaptic concentration of serotonin. Also described is the activation of cell surface serotonin receptors by dexnorfenfluramine. Agents which cause the activation of cell surface serotonin receptors can be administered to an individual to stimulate non-amyloidogenic processing in the brain of the individual, thereby inhibiting the deposition of amyloid in the brain of the individual.
Claims29
A method of preventing, delaying or reducing the formation of amyloid plaques deposited in the brain of an individual in need thereof comprising administering to said individual a therapeutically effective amount of an agent selected from the group consisting of dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan.
A method of preventing, delaying or reducing the formation of amyloid plaques associated with a disease in which amyloid is deposited in the brain of an individual, by decreasing amyloidogenic APP processing in cells of the central nervous system of the individual, comprising administering to the individual in need thereof, a therapeutically effective dose of an agent selected from the group consisting of:
- dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan, wherein the agent is administered to the individual in such a manner that the agent contacts cells in the central nervous system.
A method of preventing, delaying or reducing the formation of amyloid plagues associated with a disease in which amyloid is deposited in the brain of an individual, comprising administering to the individual in need thereof, a therapeutically effective dose of an agent selected from the group consisting of:
- dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan, wherein the agent is administered to the individual in such a manner that the agent contacts cells in the brain which have the cell surface serotonin receptor.
A method of treating Alzheimer's disease in an individual in which amyloid is deposited in the brain, comprising administering to the individual a therapeutically effective dose of an agent selected from the group consisting of:
- dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan, in such a manner that the agent contacts cells in the brain which have the cell surface serotonin receptor.
A method of treating an individual who has Alzheimer's disease in which amyloid is deposited in the brain, comprising administering to the individual a therapeutically effective dose of dexnorfenfluramine.
A method of alleviating or delaying the progression of Alzheimer's disease in which amyloid is deposited in the brain of an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent selected from the group consisting of:
- dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan.
A method of treating Alzheimer's disease in an individual in need thereof comprising administering to said individual a therapeutically effective amount of an agent selected from the group consisting of dexnorfenfluramine, dexfenfluramine, fenfluramine, fluoxetine, sertraline, paroxetine, fluvoxamine, tryptophan and 5-hydroxytryptophan.
Dependencies are inferred from the claim text.