Pleasant-tasting aqueous liquid composition of a bitter-tasting drug
AssigneeAscent Pediatrics, Inc.
InventorsAloysius O. Anaebonam, Emmett Clemente, Abdel A. Fawzy
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Abstract
A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a bitter tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol. That aqueous medium consists essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone, about 35 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants. The liquid composition is transparent and has a pleasant taste. The bitter tasting drugs claimed herein are vitamin and mineral preparations, trimethoprim, and guaifenesin.
Claims30
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of a bitter-tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone, about 35 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said liquid composition being transparent and having a pleasant taste when administered orally, wherein said bitter-tasting drug is selected from the group consisting of a vitamin preparation and minerals.
A liquid pharmaceutical composition comprising about 0.5 to about 5 weight percent of a bitter-tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 7 to about 15 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said ammonium glycyrrhizinate being present at a weight ratio to said drug of about 1:50 to about 1:10 and said liquid composition being transparent and having a pleasant taste when administered orally, wherein said bitter-tasting drug is selected from the group consisting of a vitamin preparation or minerals.
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of trimethoprim dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 7 to about 15 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said liquid composition being transparent and having a pleasant taste when administered orally.
A liquid pharmaceutical composition comprising about 0.5 to about 5 weight percent of trimethoprim dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 7 to about 15 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said ammonium glycyrrhizinate being present at a weight ratio to said trimethoprim of about 1:50 to about 1:10 and said liquid composition being transparent and having a pleasant taste when administered orally.
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 7 to about 15 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said liquid composition being transparent and having a pleasant taste when administered orally.
A liquid pharmaceutical composition comprising about 0.5 to about 5 weight percent of guaifenesin dissolved or dispersed in an aqueous medium that is free of ethanol, said aqueous medium consisting essentially of water, about 7 to about 15 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants, said ammonium glycyrrhizinate being present at a weight ratio to said guaifenesin of about 1:50 to about 1:10 and said liquid composition being transparent and having a pleasant taste when administered orally.
Dependencies are inferred from the claim text.