Therapeutic active agent for treatment of neuron degenerative diseases
AssigneePolifarma S.p.A.
InventorsCinzia Piazza, Vincenzo Politi, Mario Materazzi, deceased
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Abstract
Uridine is a therapeutic agent active as a growth promoter for treatment of neuron degenerative diseases deriving from pathological ageing or selective destruction, in particular Uridine shows the same biological effects as NGF, when added at low doses to the culture medium, so that uridine may replace NGF as therapeutic agent in neural diseases and it may be also associated with other growth factors that allow differentiation of neurons, or with anti-cancer and anti-virus drugs that cause neuron damage. In addition uridine shows important trophic properties on various types of cultured cells, stimulating cell reproduction when used at rather high dose levels.
Claims31
A method for the treatment of disturbances of the nervous system due to degeneration of neuronal or glial cells in mammals, comprising administering to said mammals an effective amount of uridine to counteract said degeneration by stimulating cell growth.
A method for counteracting selective degeneration in neuronal or glial cells of a mammal, wherein said degeneration produces a disturbance in the nervous system of said mammal, comprising administering to said mammal an effective amount of uridine to promote differentiation and functioning and maturation of said cells.
In a method for promoting an action counteracting a selective degeneration of neuronal or glial cells of a mammal, said degeneration being associated with disturbances in the nervous system of said mammal which can be treated by administering to said mammal a therapeutically effective amount of neurotrophins, the improvement comprising administering to said mammal an effective amount of uridine in place of said neurotrophins to stimulate cell growth and promote differentiation and functioning and maturation of said cells.
A composition for treating disturbances of the nervous system due to selective degeneration of neuronal or glial cells in mammals by stimulating cell growth and promoting differentiation and functioning and maturation of said cells comprising a pharmaceutically effective amount of uridine and at least one neurotrophin, wherein the proportion of uridine or neurotrophin is from 1:10 to 1:100 and pharmaceutically acceptable carriers and diluents.
Dependencies are inferred from the claim text.