Triazine derivative and medicine
AssigneeNippon Shinyaku Co., Ltd.
InventorsFusao Ueda, Takayuki Ozaki, Ken-ichi Nakamura
Life of this patent
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Abstract
The invention relates to a medicinal composition comprising a triazine derivative of the following general formula I! ##STR1## or a solvate thereof, or a salt thereof, as an active ingredient. In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl aralkyl, or alkenyl, or jointly represent cyclic amino (NR.sup.1 R.sup.2) in combination with the adjacent nitrogen atom. The cyclic amino may contain nitrogen, oxygen, or sulfur as a ring member in addition to the adjacent nitrogen and may be further substituted. Excluded is the case in which NR.sup.1 R.sup.2 is NH.sub.2. The compound of the invention is useful as a therapeutic drug for hepatitis.
Claims18
A compound of the following general formula I! or a salt thereof, or a hydrate or an ethanolate thereof, ##STR10## wherein R.sup.1 and R.sup.2 may be the same or different and each represents (1) hydrogen, (2) substituted alkyl, (3) unsubstituted or substituted aralkyl, (4) unsubstituted or substituted aralkenyl, or (5) unsubstituted or substituted aryl, or R.sup.1 and R.sup.2, jointly and taken together with the adjacent N atom, represent a 4- through 8-membered cyclic amino group of the formula NR.sup.1 R.sup.2 ;
- the cyclic amino group may further contain, nitrogen, oxygen, or sulfur as a ring member and is substituted;
- provided, that the case in which both of R.sup.1 and R.sup.2 represent hydrogen and the case in which NR.sup.1 R.sup.2 forms an unsubstituted ring are excluded.
A method for the treatment of mammals, including humans, suffering from hepatitis, which comprises administering to said sufferer an antihepatitis effective amount of a compound of formula I! or a pharmaceutically acceptable salt thereof or a hydrate or an ethanolate thereof, ##STR11## wherein R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl, aralkyl, aralkenyl, or aryl, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form unsubstituted or substituted cyclic amino having 4 to 8 ring members, said cyclic amino containing the depicted nitrogen atom as the sole heteroatom or containing nitrogen, oxygen, or sulfur as a second heteroatom;
- provided, however, that when one of R.sup.1 and R.sup.2 is hydrogen the other may not be hydrogen.
A composition for the treatment of mammals, including humans, suffering from hepatitis, which comprises a therapeutically effective amount for the treatment of hepatitis of a compound of formula I! or a pharmaceutically acceptable salt thereof or a hydrate or an ethanolate thereof together with a pharmaceutically acceptable carrier therefor:
- ##STR12## wherein R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl, aralkyl, aralkenyl, or aryl, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form unsubstituted or substituted cyclic amino having 4 to 8 ring members, said cyclic amino containing the depicted nitrogen atom as the sole heteroatom or containing nitrogen, oxygen, or sulfur as a second heteroatom;
- provided, however, that when one of R.sup.1 and R.sup.2 is hydrogen the other may not be hydrogen.
Dependencies are inferred from the claim text.