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US 5,962,439 AGranted
Fused benzeneoxyacetic acid derivatives
AssigneeOno Pharmaceutical Co., Ltd.
InventorsNobuyuki Hamanaka, Kanji Takahashi, Hidekado Tokumoto
Life of this patent
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Abstract
Fused benzeneoxyacetic acid derivatives of the formula (I): ##STR1## or salts thereof possess an agonistic effect on the PGI.sub.2 receptor and thus are useful for preventing and/or treating thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension. A, B, D, and R.sup.1 are as defined in the specification.
Claims16
A fused benzeneoxyacetic acid derivative of the formula (I):
- ##STR153## R.sup.1 is (i) hydroxy,
- (ii) C.sub.1-12 alkoxy or
- (iii) NR.sup.2 R.sup.3 ;
- R.sup.2 and R.sup.3 each, independently, is
- (i) hydrogen atom or
- (ii) C.sub.1-4 alkyl or
- R.sup.2 and R.sup.3 together with the nitrogen atom is an amino acid;
- R.sup.4 each, independently, is
- (i) hydrogen atom,
- (ii) C.sub.1-4 alkyl,
- (iii) phenyl or
- (iv) C.sub.1-4 alkyl substituted with one or two rings optionally selected from 4-7 membered monocyclic hetero ring containing one or two nitrogen atoms, and phenyl;
- when R.sup.4 is phenyl or a group containing phenyl or a 4-7 membered monocyclic hetero ring containing one or two nitrogen atoms, said phenyl and hetero ring may be substituted with one to three of C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen atom, nitro group or trihalomethyl group;
- e is 3-5;
- f is 1-3;
- m is 1 or 2;
- p is 1-4;
- q is 0-2;
- r is 1-4;
- and s is 0-3;
- with the provisos that,
- (1) when A is ##STR154## and R.sup.4 is a hydrogen atom, q or s is not zero;
- (2) when A is ##STR155## and R.sup.4 is a C.sub.1-4 alkyl substituted with a hetero ring, a hetero ring in R.sup.4 is bonded to the alkyl via a carbon atom in the hetero ring;
- (3) --(CH.sub.2).sub.r -- or .dbd.CH--(CH.sub.2).sub.s -- is bonded to the carbon atom at the a or b position of the ring;
- (4) and when A is ##STR156## R.sup.4 is a C1-4 alkyl group substituted with one or two 4-7 membered monocyclic hetero rings containing one or two nitrogen atoms;
- or non-toxic salts thereof or non-toxic acid addition salts thereof.
23 more elements
Dependencies are inferred from the claim text.