In vivo gene transfer methods for wound healing
AssigneeThe Regent of the University of Michigan
InventorsSteven A. Goldstein, Jeffrey Bonadio
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Abstract
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.
Claims14
A method for transferring a DNA molecule that directs the expression of a gene product into a mammalian repair cell, comprising applying a biocompatible matrix containing the DNA molecule to a wound in a mammalian subject, so that repair cells at the wound site acquire the DNA molecule, and express the gene product in vivo.
A method for transferring a DNA molecule that directs the expression of a gene product into a mammalian repair cell, comprising applying a biocompatible matrix containing the DNA molecule to a wound in a mammalian subject, wherein said matrix is sufficient to allow infiltration of repair cells, so that repair cells at the wound site acquire the DNA molecule, and express the gene product in vivo.
Dependencies are inferred from the claim text.