Methods and compositions for targeting selectins
AssigneeArch Development Corporation
InventorsDennis E. Hallahan, Ralph R. Weichselbaum
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Abstract
Disclosed are a variety of compositions and methods for use in specifically targeting the L-selectin or preferably, the E-selectin marker following its cell surface induction, e.g., using ionizing radiation, in tumor vasculature endothelial cells. The compositions and methods described are suitable for use in the delivery of selected agents to tumor vasculature, as may be used in the diagnosis aid therapy of solid tumors.
Claims25
A method for delivering a selected agent to vascular endothelial cells of an animal, comprising inducing E-selectin or L-selectin expression in said vascular endothelial cells in said animal with ionizing radiation and administering to said animal a composition comprising an E-selectin or L-selectin targeting component and a selected agent, whereby the agent is delivered to vascular endothlelial cells by said targeting component.
A method of delivering a protein to the vascular endothelial tissue of an animal comprising inducing E-selectin or L-selectin in cells of said vascular endothelial tissue with ionizing radiation and administering a T lymphocyte containing a recombinant vector that expresses said protein, whereby said protein agent is delivered to vascular endothelial tissues.
Dependencies are inferred from the claim text.