Fibrin sealant compositions and methods for utilizing same
AssigneeBristol-Myers Squibb Company
InventorsPeter A. D. Edwardson, John E. Fairbrother, Ronald S. Gardner, Derek A. Hollingsbee, Stewart A. Cederholm-Williams
Life of this patent
Estimating the term…
Abstract
The subject invention relates to fibrin sealants. More specifically, the subject invention relates to the use of a fibrin sealant wherein a composition comprising fibrin monomer or a composition comprising noncrosslinked fibrin is utilized as a component of the fibrin sealant.
Claims13
An aqueous composition comprising
- (a) fibrin monomer;
- (b) a source of calcium ions wherein the concentration of said calcium ions is between 5 mM and 150 mM;
- and
- (c) an adjuvant selected from the group consisting of antibiotics, histamine H.sub.2 -antagonists and anticancer drugs.
A solid support selected from the group consisting of a bandage, suture, prosthesis and a dressing, which has on its surface a composition comprising fibrin monomer and an adjuvant selected from the group consisting of antibiotics, histamine H.sub.2 -antagonists and anticancer drugs.
A kit comprising
- (a) a composition comprising fibrin monomer and an adjuvant selected from the group consisting of antibiotics, histamine, H.sub.2 -antagonists and anticancer drugs;
- and
- (b) a composition selected from the group consisting of alkaline buffer or distilled water.
A method for delivering a drug to a desired site comprising the steps of
- (a) providing a fibrin monomer component to form a fibrin sealant;
- and
- (b) delivering said drug to said site by co-administering said drug and said sealant.
A kit comprising separately:
- (a) a first component comprising fibrin monomer;
- and
- (b) a second component comprising an alkaline buffer or distilled water
- wherein said fibrin monomer is in a powder or lyophilized form which can be reconstituted with water prior to use.
A kit comprising separately:
- (a) a first component comprising fibrin monomer;
- and
- (b) a second component comprising an alkaline buffer or distilled water
- wherein said first component further includes an adjuvant selected from the group consisting of antibiotics, anticancer drugs, histamine H.sub.2 -antagonists, fibronectin and fibrinolytic inhibitors.
A kit comprising separately:
- (a) a first component comprising noncrosslinked fibrin;
- and
- (b) a second component comprising calcium ions
- wherein said first component further includes an adjuvant selected from the group consisting of antibiotics, anticancer drugs, histamine H.sub.2 -antagonists, fibronectin and fibrinolytic inhibitors.
A kit comprising separately:
- (a) a first component comprising noncrosslinked fibrin;
- and
- (b) a second component comprising calcium ions
- which further comprises activated factor XIII.
Dependencies are inferred from the claim text.