Factor VII-derived peptides
AssigneeNycomed Imaging A/S
InventorsKjell Steinar Sakariassen, Ross Wentworth Stephens, Lars Orning
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds comprising the amino acid sequences of the formulae (IA): -CVNENGGCEQYCSD-, (IB): -FCLPAFEGRNCE- and/or (IC): -RCHEGYSLLADGVSCT- as well as peptide fragments thereof, esters, amides, salts and cyclic derivatives thereof, functional analogues thereof and extended peptide chains carrying amino acids or peptides at the termini of the above sequences or fragments, for use in the prevention or inhibition of binding of tissue factor to FVII.
Claims15
A peptide having an amino acid sequence consisting of;
- CVNENGGCEQYCSD (SEQ ID NO:
- 4), IA FCLPAFEGRNCE (SEQ ID NO:
- 5), IB RCHEGYSLLADGVSCT (SEQ ID NO:
- 6), IC
- or esters, amides, salts or cyclic derivatives thereof or functional analogues or fragments thereof having substantially similar activity to peptides IA, IB and IC, wherein said fragments have at least five amino acids and exclude the peptides
- CVNEGGCEQYC (SEQ ID NO:
- 7) IIA CLPAFEGRNC (SEQ ID NO:
- 8) IIB and CHEGYSLLADGVSC (SEQ ID NO:
- 9). IIC
A method for preventing formation of a functional tissue factor/FVIIa complex comprising applying a pharmaceutical composition comprising peptides having an amino acid sequence consisting of:
- CVNENGGCEQYCSD (SEQ ID NO:
- 4), IA FCLPAFEGRNCE (SEQ ID NO:
- 5), IB RCHEGYSLLADGVSCT (SEQ ID NO:
- 6), IC
- or esters, amides, salts or cyclic derivatives thereof, or analogues or fragments thereof, said esters, amides, salts, cyclic derivatives, analogues or fragments having substantially similar ability to prevent formation of functional tissue factor/FVIIIa complex as peptides IA, IB or IC.
A peptide selected from the group consisting of:
- CVNENGGCEQYCSD (SEQ ID NO:
- 4) IA, FCLPAFEGRNCE (SEQ ID NO:
- 5) IB, and RCHEGYSLLADGVSCT (SEQ ID NO:
- 6). IC
A peptide selected from the group consisting of:
- VNENG (SEQ ID NO:
- 10), ENGGC (SEQ ID NO:
- 12), GGCEQ (SEQ ID NO:
- 14), CEQYV (SEQ ID NO:
- 15), NGGCEQYCSD (SEQ ID NO:
- 11) and GGCEQYCSD (SEQ ID NO:
- 13).
A peptide selected from the group consisting of:
- ENGGA (SEQ ID NO:
- 16), GGAEQ (SEQ ID NO:
- 17) and AEQYV (SEQ ID NO:
- 18).
A peptide having an amino acid sequence consisting of EQYVNE (SEQ ID NO:
- 19).
Dependencies are inferred from the claim text.