Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof

Abstract

Novel compositions of immunosuppressants, such as cyclosporin, and polypeptide inhibitors of cytoplasmic protein nuclear translocation are disclosed. The compositions have, in addition to at least one immunosuppressant, at least one polypeptide inhibitor of nuclear translocation that has a signal sequence and at least one, preferably two, nuclear localization sequences. The compositions are useful as immunosuppression, antiviral and antitumor agents, preferably to prevent rejection of transplanted organs or tissue.

Dependencies are inferred from the claim text.