Modified Bowman-Birk inhibitor
OwnerYehudith Birkinventor
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Abstract
Composition and method for suppression and inhibition of carcinogenesis comprising a modified Bowman-Birk inhibitor (BBI) comprising an active chymotrypsin inhibitory site, and a deactivated trypsin inhibitory site. The modified Bowman-Birk Inhibitor has been prepared by specifically acetylating a lysine residue with acetic anhydride.
Claims9
A composition for suppression and inhibition of carcinogenesis comprising a modified Bowman-Birk inhibitor (BBI) comprising an active chymotrypsin inhibitory site, and a deactivated acetylated trypsin inhibitory site which has been acetylated by acetic anhydride.
A method for preparing a modified Bowman-Birk inhibitor (BBI) composition, comprising:
- acetylating a BBI containing solution containing chymotrypsin and trypsin inhibitory sites with acetic anhydride to selectively acetylate and deactivate the trypsin inhibitory site only, and recovering the modified BBI product.
A method for inhibiting carcinogenesis in an animal which is susceptible to cancer comprising:
- administering to said animal an effective amount of a modified Bowman-Birk inhibitor (BBI) composition comprising an active chymotrypsin inhibitory site and a deactivated acetylated trypsin inhibitory site which has been acetylated by acetic anhydride.
Dependencies are inferred from the claim text.