US 5,962,411 A · Human growth hormone variants and methods of administering same

Abstract

There is provided a DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2(88) and hGHV-3(53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type hGH. The growth hormone variants of the present invention are of human origin and are useful for diagnostic preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.

Claims50

Dependent claims

An isolated polypeptide comprising:

an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence shown as residues 1 to 172 of SEQ ID NO:5;
(b) the amino acid sequence shown as residues 1 to 151 of SEQ ID NO:6;
(c) the amino acid sequence of a fragment of hGHV-2(88) which is an hGH agonist;
and
(d) the amino acid sequence of a fragment of hGHV-3(53) which is an hGH antagonist.

3 more elements

Dependencies are inferred from the claim text.

Human growth hormone variants and methods of administering same

Life of this patent

Human growth hormone variants and methods of administering same

Life of this patent

Abstract

Claims50