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US 5,962,409 AGranted
Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone
OwnerRomano Deghenghiinventor
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Abstract
Cyclic peptides of general formula (I), wherein the groups are as described in the disclosure, having inhibitory activity on growth hormone. The peptides of formula (I) have also anticancer activity. ##STR1##
Claims8
Compounds of formula (I) ##STR7## wherein A is D-AlkTrp, D-.beta.-Nal or D-Phe;
- B is Tyr or Phe;
- C is Val or Thr;
- R is ThrNH.sub.2 or AlkTrpNH.sub.2 ;
- with at least one of A or R being D-AlkTrp or AlkTrpNH.sub.2, respectively;
- or the pharmaceutically acceptable salts of said compounds;
- wherein AlkTrp is an alkyl group of one to three carbon atoms;
- with the proviso that when A is D-.beta.-Nal, B is not Tyr, C is not Val and R is not ThrNH.sub.2.
4 more elements
Dependencies are inferred from the claim text.