Enzymatically-produced oligodendrocyte cytotoxic dimeric IL-2 factor
AssigneeYeda Research and Development Co. Ltd.
InventorsMichal Eisenbach-Schwartz, Shoshana Eitan
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Abstract
An enzymatically-producible dimeric IL-2 such as mammalian, more particularly, human dimeric IL-2, having oligodendrocyte cytotoxic activity, is useful as active ingredient of pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals, including humans.
Claims5
A human enzymatically-producible dimeric IL-2 being water-soluble, being a covalent dimer of human IL-2, being selectively toxic to the oligodendrocyte lineage, which toxicity is neutralized by antibodies directed against IL-2, being obtainable from human IL-2 by incubation with transglutaminase, and having a molecular weight of about 30 kDa as determined by Western blot analysis.
A pharmaceutical composition for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals comprising a pharmaceutically effective amount of an enzymatically-producible dimeric IL-2 having oligodendrocyte cytotoxic activity and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.