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US 5,962,317 AGranted
Dosage modeling system
AssigneeThe Johns Hopkins University School of Medicine
InventorsFayez M. Hamzeh, Paul S. Lietman
Life of this patent
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Abstract
A monitoring system such as a drug dosage modeling system is disclosed. In preferred embodiments, the system provides mixing without the need for mechanical stirring.
Claims37
A method of monitoring the effect of at least one therapeutic agent on cells comprising:
- circulating a simulated body fluid along a first circulation loop in fluid communication with a central reservoir and bioreactor including cells;
- mixing at least one therapeutic agent with said simulated body fluid;
- wherein mixing the therapeutic agent with said simulated body fluid includes passing the therapeutic agent and the body fluid through a mixing arrangement into the central reservoir, said mixing arrangement including a therapeutic agent port and a simulated body fluid port cooperatively arranged to allow the simulated body fluid to wash the therapeutic agent from the therapeutic agent port;
- and
- monitoring the effect of the therapeutic agent on the cells in the bioreactor and determining a result.
2 more elements
A method of monitoring the effect of a therapeutic agent on cells comprising:
- operating a plurality of monitoring systems, each monitoring system:
- circulating a simulated body fluid along a first circulation loop in fluid communication with a central reservoir and a bioreactor including cells;
- mixing the simulated body fluid with a therapeutic agent with a diluent fluid;
- wherein mixing the simulated body fluid with the therapeutic agent and the diluent fluid includes passing the body fluid, the therapeutic agent, and the diluent fluid through a mixing arrangement into the central reservoir, said mixing arrangement including a simulated body fluid port, a diluent fluid port, and a therapeutic agent port, wherein the ports are cooperatively arranged to allow the simulated body fluid to wash:
- the therapeutic agent from the therapeutic agent port, and the diluent fluid from the diluent fluid port;
- monitoring the effect of the therapeutic agent on the cells in the bioreactor and determining a result;
- and
- comparing the result from each monitoring system.
5 more elements
A method of monitoring the effect of a therapeutic agent on cells comprising:
- operating a plurality of monitoring systems, each monitoring system:
- circulating a simulated body fluid along a first circulation loop in fluid communication with a central reservoir and a bioreactor including cells;
- mixing a therapeutic agent with said simulated body fluid;
- wherein mixing the therapeutic agent with said simulated body fluid includes passing the therapeutic agent and the body fluid through a mixing arrangement into the central reservoir, said mixing arrangement including a therapeutic agent port and a simulated body fluid port cooperatively arranged to allow the simulated body fluid to wash the therapeutic agent from the therapeutic agent port;
- monitoring the effect of the therapeutic agent on the cells in the bioreactor and determining a result;
- and
- comparing the result from each monitoring system.
4 more elements
A method of monitoring the effect of a therapeutic agent on cells comprising:
- circulating a simulated body fluid along a first circulation loop in fluid communication with a bioreactor including cells and a dosing element capable of passing a therapeutic agent into the first circulation loop;
- passing the therapeutic agent into the first circulation loop and mixing the therapeutic agent with said simulated body fluid wherein said mixing includes passing the therapeutic agent and said simulated body fluid through a mixing arrangement arranged to allow the therapeutic fluid and said simulated body fluid to contact each other, and wherein the mixing does not require a magnetic stirrer;
- removing a mixture of therapeutic agent and simulated body fluid from the first circulation loop;
- and
- monitoring the effect of the therapeutic agent on the cells in the bioreactor and determining a result.
2 more elements
Dependencies are inferred from the claim text.