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AssigneesNPS Pharmaceuticals, Inc., The Brigham and Women's Hospital, Inc.
InventorsEdward M. Brown, Steven C. Hebert, James E. Garrett, Jr.
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The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
An expression vector comprising at least 20 contiguous nucleotides of a nucleic acid sequence from nucleotide 515 to 3769 of SEQ ID NO:
An expression vector comprising at least 27 contiguous nucleotides of a nucleic acid sequence from nucleotide 515 to 3769 of SEQ ID NO:
An expression vector comprising at least 45 contiguous nucleotides of a nucleic acid sequence from nucleotide 515 to 3769 of SEQ ID NO:
An expression vector comprising a nucleic acid sequence selected from the group consisting of:
An expression vector comprising a nucleic acid sequence encoding at least 12 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
An expression vector comprising a nucleic acid sequence encoding at least 18 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
An expression vector comprising a nucleic acid sequence encoding at least 54 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
An expression vector comprising a nucleic acid sequence encoding an amino acid sequence selected from the group consisting of SEQ ID NO:
A recombinant nucleic acid comprising at least 20 contiguous nucleotides of a sequence from nucleotide 515 to 3769 of SEQ ID NO:
A recombinant nucleic acid comprising at least 27 contiguous nucleotides of a sequence from nucleotide 515 to 3769 of SEQ ID NO:
A recombinant nucleic acid comprising at least 45 contiguous nucleotides of a sequence from nucleotide 515 to 3769 of SEQ ID NO:
A recombinant nucleic acid comprising a nucleic acid sequence selected from the group consisting of:
A recombinant nucleic acid comprising a nucleic acid sequence encoding at least 12 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
A recombinant nucleic acid comprising a nucleic acid sequence encoding at least 18 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
A recombinant nucleic acid comprising a nucleic acid sequence encoding at least 54 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
A recombinant nucleic acid comprising a nucleic acid sequence encoding an amino acid sequence selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.